Beilstein J. Org. Chem.2019,15, 1289–1297, doi:10.3762/bjoc.15.127
catalytic Michael reaction itself was carried out with high diastereoselectivity, but the Michael adducts may epimerize at the C-2 position at a significant rate. Conditions for the preparation of individual diastereomers were found.
Keywords: asymmetric catalysis; chiraldiamineligands; ketosulfones
Beilstein J. Org. Chem.2013,9, 313–322, doi:10.3762/bjoc.9.36
) and (1S,2S)-1,2-dimethoxy-1,2-diphenylethane (L10) are particularly effective surrogates for sparteine, affording 3-methylindoline (R)-38a in good yield and high enantiomeric excess (Scheme 14). With regard to chiraldiamineligands, enantiomeric excess is only maintained by using cis-1,5-diazadecalin